UCCRC Core Facilities: Pharmacology

Scientific Director:  M. Eileen Dolan, PhD

Technical Directors:  Jacqueline Ramirez, MS and Shannon Delaney, MS

Analytical Core Phone: 773-834-2451

Biochemical Core Phone: 773-702-1236

Web Site:   http://pharmacology.bsd.uchicago.edu/

The Pharmacology Core Facility evaluates pharmacokinetic, pharmacodynamic, and pharmacogenetic parameters in conjunction with clinical trials. The Facility is comprised of an Analytical Core and a Biochemical Core. The Analytical Core is responsible for assays of various pharmacological targets, the development of pharmacological assays of anti-cancer agents and their metabolites, and the analysis of drug and metabolite concentrations in biological fluids.  The Biochemical Core is responsible for the assessment of markers for drug resistance and measurement of drug-metabolizing enzyme activity in human tissue. 

Services

Analytical Services:

  • Analysis of drug levels in biological fluids (whole blood, plasma, urine).

Biochemical Services

  • Sample transportation (from the General Clinical Research Center or outpatient clinic to the Facility) and storage;
  • Plasma and lymphocyte isolation from whole blood;
  • DNA and RNA Isolation; and
  • Assessment of markers for drug resistance.